Chembiotech: 7-Deaza-dG (ibu) CE-phosphoramidite

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Modified Phosphoramidites , class 7-Deazapurine Nucleoside Phosphoramidites

Catalog #	CBT-P-021
Compound	7-Deaza-dG (ibu) CE-phosphoramidite
Chemical Name	7-[2-Deoxy-5-O-(4,4'-dimethoxytrityl)-ß-D-erythro-pentofuranosyl]-3,7-dihydro-2-[(isobutyryl)amino]-4H-pyrrolo[2,3-d]pyrimidin-4-one 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
Formula	C₄₅H₅₅N₆O₈P
Molecular Weight	838.93 g/mol
Properties	Storage at -18°C Phosphoramidites of 7-deaza-2’-deoxyguanosine (7-deaza-dG) were first prepared in 1985 by Seela and co-workers. Oligonucleotides containing 7-deaza-dG give higher sensitivity in MALDI-TOF spectrometry due to the rather stable glycosidic bond under acidic conditions. The incorporation of this modified nucleoside in place of dG destroys dG-quartets, thereby prohibiting oligonucleotide aggregation during gel electrophoresis or PCR-amplification. Multiple incorporations of 7-deaza-dG might require milder oxidation reagents or the use of our product CBT-P-160.
Appearance	Off-white foam
References	F. Seela, H. Driller, Nucleic Acids Res. 1985, 13, 911. F. Seela, H. Driller, Nucleic Acids Res. 1989, 17, 901.

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