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7-Deaza-dG (ibu) CE-phosphoramidite
Modified Phosphoramidites , class 7-Deazapurine Nucleoside Phosphoramidites
7-Deaza-dG (ibu) CE-phosphoramidite
Catalog # CBT-P-021
Compound 7-Deaza-dG (ibu) CE-phosphoramidite
Chemical Name 7-[2-Deoxy-5-O-(4,4'-dimethoxytrityl)-ß-D-erythro-pentofuranosyl]-3,7-dihydro-2-[(isobutyryl)amino]-4H-pyrrolo[2,3-d]pyrimidin-4-one 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
Formula C45H55N6O8P
Molecular Weight 838.93 g/mol
Properties Storage at -18°C

Phosphoramidites of 7-deaza-2-deoxyguanosine (7-deaza-dG) were first prepared in 1985 by Seela and co-workers. Oligonucleotides containing 7-deaza-dG give higher sensitivity in MALDI-TOF spectrometry due to the rather stable glycosidic bond under acidic conditions. The incorporation of this modified nucleoside in place of dG destroys dG-quartets, thereby prohibiting oligonucleotide aggregation during gel electrophoresis or PCR-amplification. Multiple incorporations of 7-deaza-dG might require milder oxidation reagents or the use of our product CBT-P-160.
Appearance Off-white foam
References F. Seela, H. Driller, Nucleic Acids Res. 1985, 13, 911.
F. Seela, H. Driller, Nucleic Acids Res. 1989, 17, 901.
QuantityPricing (EUR)
50 µmol 180,00
100 µmol 320,00
250 mg 850,00
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