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Research and Development

Nucleosides and Phosporamidites: Synthesis and Application

  • Synthesis of base-modified nucleosides (azapurine and deazapurine nucleosides) mimicking the shape of canonical DNA or RNA constituents
  • Synthesis of heterocycles related to canonical nucleobases including halogenated derivatives
  • Synthesis of carbohydrates, including fluoro sugars, L-sugars and other modified sugar derivatives
  • Development of stereoselective glycosylation techniques
  • Synthesis of fluorescent nucleosides or nucleosides carrying reporter groups
  • Development of nucleosides showing antiviral or anticancer activity